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Noribogaine also elevates serotonin concentrations in the Mind, a probable rationalization for its antidepressive outcomes. The sustained presence of noribogaine during the CNS coupled with its agonist activity at opioid receptors might make the self-tapering result in opiate-dependent clients adhering to abrupt discontinuation of opiates. Also, ibogaine will be able to change the expression of several proteins, substance P, and brain-derived neurotrophic variable. Noribogaine is likely to be fewer neurotoxic than ibogaine.Litjens 2016
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